Midazolam hydrochloride

Name: Midazolam hydrochloride
Brand: Tocris Bioscience
SKU: 2832
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2832

(1)

Citations (2)

COA / SDS

Benzodiazepine agonist

Key Product Details

Description:	Benzodiazepine agonist
Alternative Names:	Dormicum,Ro 21-3981/001
Chemical Name:	8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	362.23

View Full Technical Details for Midazolam hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Midazolam hydrochloride

Midazolam hydrochloride is a sedative/hypnotic agent that acts at the GABA_A receptor benzodiazepine modulatory site.

Technical Data for Midazolam hydrochloride

M. Wt	362.23
Formula	C₁₈H₁₃ClFN₃.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	59467-96-8
PubChem ID	43032
InChi Key	PLYSCVSCYOQVRP-UHFFFAOYSA-N
Smiles	FC(C=CC=C4)=C4C3=NCC1=CN=C(C)N1C2=CC=C(Cl)C=C23.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Midazolam hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	9.06	25

Preparing Stock Solutions for Midazolam hydrochloride

The following data is based on the product molecular weight 362.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.04 mL	55.21 mL	110.43 mL
1.25 mM	2.21 mL	11.04 mL	22.09 mL
2.5 mM	1.10 mL	5.52 mL	11.04 mL
12.5 mM	0.22 mL	1.10 mL	2.21 mL

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Reconstitution Calculator

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References for Midazolam hydrochloride

References are publications that support the biological activity of the product.

Olkkola and Ahonen Midazolam and other benzodiazepines. Handb.Exp.Pharmacol. 2008 PMID: 18175099
Kanto Midazolam: the first water-soluble benzodiazepine. Pharmacology, pharmacokinetics and efficacy in insomnia and anesthesia. Pharmacotherapy 1985 PMID: 3161005