Mibefradil dihydrochloride is a Ca²⁺ channel blocker with moderate selectivity for T-type Ca²⁺ channels displaying IC₅₀ values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively. Antihypertensive agent.

Product Specifications

Molecular Weight

568.56

Formula

C₂₉H₃₈FN₃O₃.2HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride

CAS Number

116666-63-8

PubChem ID

60662

InChI Key

MTJLQTFHJIHXIX-GDUXWEAWSA-N

SMILES

Cl.Cl.COCC(=O)O[C@]1(CCN(C)CCCC2=NC3=C(N2)C=CC=C3)CCC2=C(C=CC(F)=C2)[C@@H]1C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	28.43	50
	DMSO	56.86	100

Preparing Stock Solutions for Mibefradil dihydrochloride

The following data is based on the product molecular weight 568.56

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.79 mL	17.59 mL
5 mM	0.35 mL	1.76 mL	3.52 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Veniant Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil, and amlod. J.Cardiovasc.Pharmacol. 1991 PMID: 1725005
Mehrke The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J.Pharmacol.Exp.Ther. 1994 PMID: 7996461
Osterrieder and Holck In vitro pharmacologic profile of Ro 40-5967, a novel Ca²⁺ channel blocker with potent vasodilator but weak inotropic action. J.Cardiovasc.Pharmacol. 1989 PMID: 2472524

Mibefradil dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2198

Key Product Details

Description

Alternative Names

View all Cav3.x Channel Blockers »

Product Description