Methylprednisolone

Name: Methylprednisolone
Brand: Tocris Bioscience
SKU: 4819
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4819

(1)

Citations (3)

COA / SDS

Glucocorticoid receptor agonist

Key Product Details

Description:	Glucocorticoid receptor agonist
Chemical Name:	11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
Purity:	≥98% (HPLC)
Molecular Weight:	374.47

View Full Technical Details for Methylprednisolone

Technical Data
Citations / Reviews (1)

Biological Activity for Methylprednisolone

Methylprednisolone is a glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-x_L via direct binding of the GR/STAT5 complex. Neuroprotective.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Methylprednisolone

Methylprednisolone is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Methylprednisolone

M. Wt	374.47
Formula	C₂₂H₃₀O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	83-43-2
PubChem ID	6741
InChi Key	VHRSUDSXCMQTMA-PJHHCJLFSA-N
Smiles	O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@](C(CO)=O)4O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Methylprednisolone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.45	100

Preparing Stock Solutions for Methylprednisolone

The following data is based on the product molecular weight 374.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.35 mL	26.70 mL
5 mM	0.53 mL	2.67 mL	5.34 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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Reconstitution Calculator

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References for Methylprednisolone

References are publications that support the biological activity of the product.

Xu STAT5 mediates antiapoptotic effects of methylprednis. on oligodendrocytes. J.Neurosci. 2009 PMID: 19228956
Lee Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J.Neurosci. 2008 PMID: 18354017