Memantine hydrochloride

Name: Memantine hydrochloride
Brand: Tocris Bioscience
SKU: 0773
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0773

(2)

Citations (61)

COA / SDS

NMDA antagonist; acts at ion channel site

Key Product Details

Description:	NMDA antagonist; acts at ion channel site
Chemical Name:	3,5-Dimethyl-tricyclo[3.3.1.13,7]decan-1-amine hydrochloride
Molecular Weight:	215.77

View Full Technical Details for Memantine hydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for Memantine hydrochloride

Memantine hydrochloride is an antagonist at the NMDA receptor (IC₅₀ = 0.5 -1.5 μM in vitro), binding to the ion channel site. Memantine increases BDNF protein and mRNA levels in the brain in vivo. In an animal model of Alzheimer's disease, memantine improves spatial learning and decreases deposition of Aβ plaques. Memantine has neuroprotective effects in dopaminergic neurons; stimulates release of neurotrophic factor from astroglia and reduces microglia inflammation in vitro.

Technical Data for Memantine hydrochloride

M. Wt	215.77
Formula	C₁₂H₂₁N.HCl
Storage	Store at RT
CAS Number	41100-52-1
PubChem ID	181458
InChi Key	LDDHMLJTFXJGPI-UHFFFAOYSA-N
Smiles	NC12CC3(CC(C1)(CC(C2)C3)C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Memantine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for Memantine hydrochloride

The following data is based on the product molecular weight 215.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.63 mL	23.17 mL	46.35 mL
5 mM	0.93 mL	4.63 mL	9.27 mL
10 mM	0.46 mL	2.32 mL	4.63 mL
50 mM	0.09 mL	0.46 mL	0.93 mL

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References for Memantine hydrochloride

References are publications that support the biological activity of the product.

Dong Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease. Neuropsychopharmacology 2008 PMID: 18418360
Minkeviciene Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease. J.Pharmacol.Exp.Ther. 2004 PMID: 15192085
Wu Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation. Neuropsychopharmacology 2009 PMID: 19536110
Zajaczkowski Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 1997 PMID: 9257940
Parsons Mem.: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse. Neuropharmacology 2007 PMID: 17904591
Parsons Mem. is a clinically well tolerated N-MthD.-aspartate (NMDA) receptor antagonist - a review of preclinical data. Neuropharmacology 1999 PMID: 10465680
Chen Neuroprotective concentrations of the N-MthD.-aspartate open-channel blocker Mem. are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 1998 PMID: 9697119