Megestrol Acetate
Tocris Bioscience, part of Bio-Techne | Catalog # 6285
Synthetic progesterone analog
Key Product Details
Description
Synthetic progesterone analog
Product Description
Megestrol Acetate is a synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC50 = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable.Product Specifications
Molecular Weight
384.51
Formula
C24H32O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione
CAS Number
595-33-5
PubChem ID
11683
InChI Key
RQZAXGRLVPAYTJ-GQFGMJRRSA-N
SMILES
[H][C@@]12CC[C@](C(C)=O)([C@]1(CC[C@]3([C@]2(C=C(C4=CC(CC[C@]34C)=O)C)[H])[H])C)OC(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.23 | 50 | |
| Ethanol | 7.69 | 20 |
Preparing Stock Solutions
for Megestrol Acetate
The following data is based on the product molecular weight 384.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.20 mL | 26.01 mL | 52.01 mL |
| 2.5 mM | 1.04 mL | 5.20 mL | 10.40 mL |
| 5 mM | 0.52 mL | 2.60 mL | 5.20 mL |
| 25 mM | 0.10 mL | 0.52 mL | 1.04 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tchekmedyian Megestrol acetate in cancer anorexia and weight loss. Cancer. 1992 PMID: 1739926
- Zhang and Chow The effect of mege. acetate on growth of HepG2 cells in vitro and in vivo. Clin.Cancer.Res. 2004 PMID: 15297426
Product Specific Notices for Megestrol Acetate
For research use only
⚠ WARNING: This product can expose you to chemicals including Megestrol acetate, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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