MC 1742

Name: MC 1742
Brand: Tocris Bioscience
SKU: 5727

Tocris Bioscience, part of Bio-Techne | Catalog # 5727

COA / SDS

Potent class I and IIb HDAC inhibitor

Key Product Details

Description:	Potent class I and IIb HDAC inhibitor
Chemical Name:	5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
Purity:	≥98% (HPLC)
Molecular Weight:	395.47

View Full Technical Details for MC 1742

Technical Data
Citations

Biological Activity for MC 1742

MC 1742 is a potent class I and IIb HDAC inhibitor (IC₅₀ values are 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively). Suppresses proliferation and induces apoptosis of sarcoma cancer stem cells (CSCs) at concentrations >500 nM. Also induces osteogenesis in sarcoma CSCs at concentrations of 25 - 500 nM.

Technical Data for MC 1742

M. Wt	395.47
Formula	C₂₁H₂₁N₃O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1776116-74-5
PubChem ID	49769453
InChi Key	AOFVDNFTELWRHV-UHFFFAOYSA-N
Smiles	O=C(NC(SCCCCC(NO)=O)=N1)C=C1C(C=C2)=CC=C2C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MC 1742

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.55	100

Preparing Stock Solutions for MC 1742

The following data is based on the product molecular weight 395.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.64 mL	25.29 mL
5 mM	0.51 mL	2.53 mL	5.06 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for MC 1742

References are publications that support the biological activity of the product.

Mai Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. Bioorg.Med.Chem.Lett. 2008 PMID: 18381238
Mai Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J.Med.Chem. 2006 PMID: 17004718
Di Pompo Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J.Med.Chem. 2015 PMID: 25905694