Maraviroc

Name: Maraviroc
Brand: Tocris Bioscience
SKU: 3756
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3756

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Citations (30)

COA / SDS

Selective CCR5 antagonist

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Product Description
Licensing Information
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective CCR5 antagonist

Alternative Names

UK-427857

View all Chemokine Receptor Antagonists »

Product Description

Maraviroc is a selective CCR5 antagonist; displays potent anti-HIV-1 activity. Prevents the interaction of HIV-1 gp120 and CCR5 (IC₅₀ = 6.4 nM), inhibiting HIV-1 entry. Exhibits antinociceptive effects in a rat model of neuropathic pain. Also inhibits CCL3 (MIP-1α) binding to CCR5. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Viiv.

Product Specifications

Molecular Weight

513.67

Formula

C₂₉H₄₁F₂N₅O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl- 5-methyl-4H-1,2,4-triazol-4-yl)- 8-azabicyclo[3.2.1]oct-8-yl]-1- phenylpropyl}cyclohexanecarboxamide

CAS Number

376348-65-1

PubChem ID

483407

InChI Key

GSNHKUDZZFZSJB-ILVMPNSOSA-N

SMILES

O=C(C4CCC(F)(F)CC4)N[C@@H](CCN2C3CCC2CC(N5C(C)=NN=C5C(C)C)C3)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.53	75
	Ethanol	51.37	100

Preparing Stock Solutions for Maraviroc

The following data is based on the product molecular weight 513.67

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.73 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Calculators

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

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Background References

References are publications that support the biological activity of the product.

Piotrowska Maraviroc reduces neuropathic pain through polarization of microglia and astroglia - Evidence from in vivo and in vitro studies. Neuropharmacology 2016 PMID: 27117708
Garcia-Perez New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection. J.Biol.Chem. 2011 PMID: 21118814
Kuritzkes Fresh from the pipeline - mara. Nat.Rev.Drug Discov.
Dorr Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob.Agents Chemother. 2005 PMID: 16251317