M617

Tocris Bioscience, part of Bio-Techne | Catalog # 2697

Citations (14)

COA / SDS

Selective GAL1 agonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
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Key Product Details

Description

Selective GAL1 agonist

Alternative Names

Galanin(1-13)-Gln¹⁴-bradykinin(2-9)amide

View all Galanin Receptor Agonists »

Product Description

M617 is a selective galanin GAL₁ receptor agonist (K_i values are 0.23 and 5.71 nM for GAL₁ and GAL₂ receptors respectively). Enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain.

Product Specifications

Molecular Weight

2361.68

Formula

C₁₁₂H₁₆₁N₂₉O₂₈

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

860790-38-1

PubChem ID

16158157

InChI Key

PAYBRARNTYCYOT-OTTBQUPZSA-N

SMILES

[H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Jimenez-Andrade Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 2006 PMID: 16996122
Lundstrom A galanin receptor subtype 1 specific agonist. Int.J.Pept.Res.Ther.
Mazarati Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 2006 PMID: 16699066