Lys-CoA

Tocris Bioscience, part of Bio-Techne | Catalog # 5103

Selective p300 inhibitor
Discontinued Product
5103 has been discontinued. View all Histone Acetyltransferase Inhibitors products.

Key Product Details

Description

Selective p300 inhibitor

View all Histone Acetyltransferase Inhibitors »

Product Description

Lys-CoA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo.

Product Specifications

Molecular Weight

1108.82

Formula

C31H53N10O19P3S.C2HF3O2

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

S-[2-[[(5S)-5-(Acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl]coenzyme A trifluoroacetate

SMILES

O[C@H]([C@@H]1OP(O)(O)=O)[C@@H](O[C@@H]1COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)N2C3=NC=NC(N)=C3N=C2.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.99 6.3

Preparing Stock Solutions for Lys-CoA

The following data is based on the product molecular weight 1108.82

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.063 mM 14.32 mL 71.58 mL 143.15 mL
0.315 mM 2.86 mL 14.32 mL 28.63 mL
0.63 mM 1.43 mL 7.16 mL 14.32 mL
3.15 mM 0.29 mL 1.43 mL 2.86 mL

Calculators

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Lys-CoA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Lys-CoA

For research use only

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