LY 78335

Name: LY 78335
Brand: Tocris Bioscience
SKU: 4060

Tocris Bioscience, part of Bio-Techne | Catalog # 4060

COA / SDS

Phenylethanolamine-N-methyltransferase inhibitor

Discontinued Product

4060 has been discontinued. View all Methyltransferase Inhibitors products.

Key Product Details

Description:	Phenylethanolamine-N-methyltransferase inhibitor
Chemical Name:	2,3-Dichloro-α-methylbenzylamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	226.53

View Full Technical Details for LY 78335

Technical Data
Citations

Biological Activity for LY 78335

LY 78335 is a high affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (K_i = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.

Technical Data for LY 78335

M. Wt	226.53
Formula	C₈H₉Cl₂N.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	39959-66-5
PubChem ID	11957540
InChi Key	FQTXPVLCCDQRHY-UHFFFAOYSA-N
Smiles	NC(C)C1=C(Cl)C(Cl)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LY 78335

References are publications that support the biological activity of the product.

Terry Regulation of episodic GH secretion by the central epinephrine system. J.Clin.Invest. 1982 PMID: 7054231
Grunewald Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. J.Med.Chem. 1988 PMID: 3351861
Fuller Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine. J.Med.Chem. 1973 PMID: 4683104

LY 78335

Tocris Bioscience, part of Bio-Techne | Catalog # 4060

Key Product Details

Biological Activity for LY 78335

Technical Data for LY 78335

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for LY 78335

Product Documents for LY 78335

COA

Certificate of Analysis

SDS

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