LY 354740

Name: LY 354740
Brand: Tocris Bioscience
SKU: 3246

Tocris Bioscience, part of Bio-Techne | Catalog # 3246

Citations (53)

COA / SDS

Potent and highly selective group II mGlu agonist

Key Product Details

Description:	Potent and highly selective group II mGlu agonist
Chemical Name:	(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	185.18

View Full Technical Details for LY 354740

Technical Data
Citations

Biological Activity for LY 354740

LY 354740 is a highly selective and potent agonist of group II mGlu receptors (EC₅₀ values are 5.1 and 24.3 nM at mGlu₂ and mGlu₃ receptors respectively and > 100000 nM at mGlu₄, mGlu₇, mGlu_1a and mGlu_5a receptors). Displays antianxiety and antiaddictive activity in vivo. Orally and systemically active.

Technical Data for LY 354740

M. Wt	185.18
Formula	C₈H₁₁NO₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	176199-48-7
PubChem ID	213056
InChi Key	VTAARTQTOOYTES-RGDLXGNYSA-N
Smiles	N[C@]1([C@@](O)=O)[C@@]2([H])[C@@]([C@@H]2[C@](O)=O)([H])CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 354740

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	18.52	100

Preparing Stock Solutions for LY 354740

The following data is based on the product molecular weight 185.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.40 mL	27.00 mL	54.00 mL
5 mM	1.08 mL	5.40 mL	10.80 mL
10 mM	0.54 mL	2.70 mL	5.40 mL
50 mM	0.11 mL	0.54 mL	1.08 mL

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References for LY 354740

References are publications that support the biological activity of the product.

Helton Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 1998 PMID: 9454811
Klodzinska Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models. Neuropharmacology 1999 PMID: 10608278
Schoepp LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cell expressing human glutamate receptors. Neuropharmacology 1997 PMID: 9144636