LY 288513
Tocris Bioscience, part of Bio-Techne | Catalog # 1524
Selective CCK2 antagonist
Product Description
LY 288513 is a selective CCK2 receptor antagonist (IC50 values are 16 and > 30,000 nM for CCK2 and CCK1 respectively). Displays anxiolytic and antipsychotic properties in vivo.Licensing Information
Sold with the permission of Eli Lilly and CompanyProduct Specifications
Molecular Weight
436.30
Formula
C22H18BrN3O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide
CAS Number
147523-65-7
PubChem ID
2802894
InChI Key
LMUQHXHWJWQXSD-PMACEKPBSA-N
SMILES
BrC1=CC=C(NC(=O)N2NC(=O)[C@H]([C@@H]2C2=CC=CC=C2)C2=CC=CC=C2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.63 | 100 |
Preparing Stock Solutions
for LY 288513
The following data is based on the product molecular weight 436.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.46 mL | 22.92 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Helton Central nervous system characterization of the new cholecystokininB antagonist LY288513. Pharmacol.Biochem.Behav. 1996 PMID: 8866946
- Rasmussen Electrophysiological effects of diphenylpyrazolidinone cholecystokinin-B and cholecystokinin-A antagonists on midbrain DA neurons. J.Pharmacol.Exp.Ther.
- Rasmussen CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain DA neurons. Ann.N.Y.Acad.Sci. 1994 PMID: 8185172
Product Specific Notices for LY 288513
For research use only
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