LY 288513

Name: LY 288513
Brand: Tocris Bioscience
SKU: 1524

Tocris Bioscience, part of Bio-Techne | Catalog # 1524

Citations (5)

COA / SDS

Selective CCK2 antagonist

Key Product Details

Description:	Selective CCK₂ antagonist
Chemical Name:	(4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	436.3

View Full Technical Details for LY 288513

Technical Data
Citations

Biological Activity for LY 288513

LY 288513 is a selective CCK₂ receptor antagonist (IC₅₀ values are 16 and > 30,000 nM for CCK₂ and CCK₁ respectively). Displays anxiolytic and antipsychotic properties in vivo.

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data for LY 288513

M. Wt	436.3
Formula	C₂₂H₁₈BrN₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	147523-65-7
PubChem ID	2802894
InChi Key	LMUQHXHWJWQXSD-PMACEKPBSA-N
Smiles	BrC1=CC=C(NC(=O)N2NC(=O)[C@H]([C@@H]2C2=CC=CC=C2)C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 288513

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.63	100

Preparing Stock Solutions for LY 288513

The following data is based on the product molecular weight 436.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.46 mL	22.92 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.15 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for LY 288513

References are publications that support the biological activity of the product.

Helton Central nervous system characterization of the new cholecystokininB antagonist LY288513. Pharmacol.Biochem.Behav. 1996 PMID: 8866946
Rasmussen Electrophysiological effects of diphenylpyrazolidinone cholecystokinin-B and cholecystokinin-A antagonists on midbrain DA neurons. J.Pharmacol.Exp.Ther.
Rasmussen CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain DA neurons. Ann.N.Y.Acad.Sci. 1994 PMID: 8185172