LY 2033298

Tocris Bioscience, part of Bio-Techne | Catalog # 7027

Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic
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Key Product Details

Description

Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic

View all mAChR M4 Modulators »

Product Description

LY 2033298 is a selective positive allosteric modulator of M4 receptor (KB = 200 nM, α = 35); increases the potency of acetylcholine by 40-fold. Exhibits no effect at hM1/3/5 receptors and a small effect at hM2 (KB = 1 μM α = 3.7). Potentiates other full and partial orthosteric agonists, including Carbachol, Oxotremorine-M, and McN-A343. Does not affect binding of antagonist NMS. Active in vivo. Antipsychotic.

α indicates the degree of allosteric enhancement when both orthosteric and allosteric sites are occupied (derived from the allosteric ternary complex model).

Product Specifications

Molecular Weight

311.79

Formula

C13H14ClN3O2S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide

CAS Number

886047-13-8

PubChem ID

11536903

InChI Key

CTEGQKDJTBWFHW-UHFFFAOYSA-N

SMILES

NC1=C(C(NC2CC2)=O)SC3=NC(OC)=C(Cl)C(C)=C31

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.18 100
Ethanol 6.24 20

Preparing Stock Solutions for LY 2033298

The following data is based on the product molecular weight 311.79

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.21 mL 16.04 mL 32.07 mL
5 mM 0.64 mL 3.21 mL 6.41 mL
10 mM 0.32 mL 1.60 mL 3.21 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for LY 2033298

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 2033298

For research use only

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