LSN 3318839

Name: LSN 3318839
Brand: Tocris Bioscience
SKU: 7959

Tocris Bioscience, part of Bio-Techne | Catalog # 7959

COA / SDS

Glucagon-like peptide-1 receptor (GLP1-R) positive allosteric modulator

Key Product Details

Description:	Glucagon-like peptide-1 receptor (GLP1-R) positive allosteric modulator
Chemical Name:	(R)-2-(2-(1-((R)-1-(2,6-Dichloro-3-cyclopropylphenyl)ethyl)-1H-imidazo[4,5-c]pyridin-6-yl)phenyl)propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	480.39

View Full Technical Details for LSN 3318839

Technical Data
Citations

Biological Activity for LSN 3318839

LSN 3318839 is a potent glucagon-like peptide-1 receptor (GLP1-R) positive allosteric modulator (EC₅₀ = 14 nM). Acts as a molecular glue to stabilize peptide ligand and GLP1 receptor interaction. Potentiates activity of GLP-1 (7-36) (Cat. No. 2082) and the low-affinity metabolite GLP-1 (9-36) (Cat. No. 3266). LSN 3318839 alone or in combination with Sitagliptin (Cat. No. 6816) lowers glucose levels in animal models of diabetes. LSN 3318839 is orally bioavailable.

Technical Data for LSN 3318839

M. Wt	480.39
Formula	C₂₆H₂₃Cl₂N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2764704-18-7
PubChem ID	162641136
InChi Key	JPJWHCNGSBCZMI-HUUCEWRRSA-N
Smiles	C[C@H](C1=C(C(C2CC2)=CC=C1Cl)Cl)N3C4=CC(C5=C(C=CC=C5)[C@@H](C)C(O)=O)=NC=C4N=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LSN 3318839

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.04	100

Preparing Stock Solutions for LSN 3318839

The following data is based on the product molecular weight 480.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.41 mL	20.82 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for LSN 3318839

References are publications that support the biological activity of the product.

Willard Discovery of an orally efficacious positive allosteric modulator of the glucagon-like peptide-1 receptor. J.Med.Chem. 2021 PMID: 33721487