LP 922761

Name: LP 922761
Brand: Tocris Bioscience
SKU: 6229

Tocris Bioscience, part of Bio-Techne | Catalog # 6229

COA / SDS

Potent AAK1 inhibitor; peripherally restricted

Discontinued Product

6229 has been discontinued. View all Other Kinase Inhibitors products.

Key Product Details

Description:	Potent AAK1 inhibitor; peripherally restricted
Chemical Name:	tert-Butyl (2-((3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)ethyl)(methyl)carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	410.47

View Full Technical Details for LP 922761

Technical Data
Citations

Biological Activity for LP 922761

LP 922761 is a potent AAK1 inhibitor (IC₅₀ values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α₂ or GABA_A receptors. Orally bioavailable. Peripherally restricted.

Compound Libraries for LP 922761

LP 922761 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for LP 922761

M. Wt	410.47
Formula	C₂₁H₂₆N₆O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1454808-95-7
PubChem ID	86696405
InChi Key	YNQNYIHMAZLJAV-UHFFFAOYSA-N
Smiles	CN(C(OC(C)(C)C)=O)CCNC1=NN2C(C=C1)=NC=C2C3=CC=C(C(N)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LP 922761

References are publications that support the biological activity of the product.

Kostich Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. J.Pharmacol.Exp.Ther. 2016 PMID: 27411717