Loreclezole hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1295

Subtype-selective GABAA modulator
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Key Product Details

Description

Subtype-selective GABAA modulator

View all GABA-A Receptor Modulators »

Product Description

Loreclezole hydrochloride is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitization. Inhibits homomeric ρ1 GABAC receptors.

Product Specifications

Molecular Weight

311.00

Formula

C10H6Cl3N3.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride

CAS Number

2227372-56-5

PubChem ID

45073437

InChI Key

AWKSVFLKVCVVFQ-MDZFRNKHSA-N

SMILES

Cl[H].Cl\C(=C/N1C=NC=N1)C1=C(Cl)C=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.37 5 with gentle warming
Ethanol 1.37 5 with gentle warming

Preparing Stock Solutions for Loreclezole hydrochloride

The following data is based on the product molecular weight 311.00

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 64.31 mL 321.54 mL 643.09 mL
0.25 mM 12.86 mL 64.31 mL 128.62 mL
0.5 mM 6.43 mL 32.15 mL 64.31 mL
2.5 mM 1.29 mL 6.43 mL 12.86 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Loreclezole hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Loreclezole hydrochloride

For research use only

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