Lonidamine

Tocris Bioscience, part of Bio-Techne | Catalog # 1646

Mitochondrial hexokinase inhibitor
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Key Product Details

Description

Mitochondrial hexokinase inhibitor

Alternative Names

AF 1890

View all Mitochondrial Hexokinase Inhibitors »

Product Description

Lonidamine is an anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.

Product Specifications

Molecular Weight

321.16

Formula

C15H10Cl2N2O2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid

CAS Number

50264-69-2

PubChem ID

39562

InChI Key

WDRYRZXSPDWGEB-UHFFFAOYSA-N

SMILES

OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.12 100
Ethanol 1.61 5

Preparing Stock Solutions for Lonidamine

The following data is based on the product molecular weight 321.16

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.57 mL 31.14 mL
5 mM 0.62 mL 3.11 mL 6.23 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Calculators

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Dilution Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Lonidamine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Lonidamine

For research use only

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