LM 10

Name: LM 10
Brand: Tocris Bioscience
SKU: 5794

Tocris Bioscience, part of Bio-Techne | Catalog # 5794

COA / SDS

Selective tryptophan 2,3-dioxygenase (TDO) inhibitor

Discontinued Product

5794 has been discontinued. View all Tryptophan 2,3 Dioxygenase Inhibitors products.

Key Product Details

Description:	Selective tryptophan 2,3-dioxygenase (TDO) inhibitor
Chemical Name:	6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole
Purity:	≥98% (HPLC)
Molecular Weight:	229.21

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Technical Data
Citations

Biological Activity for LM 10

LM 10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC₅₀ values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

Technical Data for LM 10

M. Wt	229.21
Formula	C₁₁H₈FN₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1316695-35-8
PubChem ID	91885138
InChi Key	FSGAFWYMLAWNJM-UHFFFAOYSA-N
Smiles	FC1=CC=C2C(NC=C2/C=C/C3=NN=NN3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LM 10

References are publications that support the biological activity of the product.

Dolusić Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 2011 PMID: 21726069
Pilotte Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 22308364

LM 10

Tocris Bioscience, part of Bio-Techne | Catalog # 5794

Key Product Details

Biological Activity for LM 10

Technical Data for LM 10

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for LM 10

Product Documents for LM 10

COA

Certificate of Analysis

SDS

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