LL-K9-3
Tocris Bioscience, part of Bio-Techne | Catalog # 7813
Selective HyT-based degrader of the CDK9-cyclin T1 complex
Key Product Details
Description
Selective HyT-based degrader of the CDK9-cyclin T1 complex
Product Description
LL-K9-3 is a selective hydrophobic tagging technologies (HyT)-based Degrader of the CDK9-cyclin T1 complex (DC50 values are 589 and 662 nM for cyclin T1 and CDK9, respectively). It comprises a CDK9 inhibitor, SNS 032 (Cat. No. 4075), joined by a glycol linker to hydrophobic tag. LL-K9-3 exhibits no degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). In 22RV1 cells. LL-K9-3 reduces expression of androgen receptor (AR) and cMyc by inducing selective and synchronous degradation of CDK9 and cyclin T1.Product Specifications
Molecular Weight
683.94
Formula
C31H49N5O6S3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-1-[[2-[[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]acetyl]amino]ethyl]sulfonyl]-4-piperidinecarboxamide
CAS Number
2809353-52-2
PubChem ID
164946948
InChI Key
NPRIWHDFWDSJRZ-YFNKSVMNSA-N
SMILES
O=S(CCNC(CO[C@H]1[C@@H](CC[C@H](C1)C)C(C)C)=O)(N2CCC(CC2)C(NC3=NC=C(SCC4=NC=C(C(C)(C)C)O4)S3)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 68.39 | 100 | |
| Ethanol | 3.42 | 5 |
Preparing Stock Solutions
for LL-K9-3
The following data is based on the product molecular weight 683.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.46 mL | 7.31 mL | 14.62 mL |
| 5 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 10 mM | 0.15 mL | 0.73 mL | 1.46 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.29 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Discovery of small-molecule degraders of the CDK9-cyclin T1 complex for targeting transcriptional addiction in prostate cancer. J.Med.Chem. 2022 PMID: 35925880
Product Specific Notices for LL-K9-3
For research use only
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