Liproxstatin-1 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6113
Potent ferroptosis inhibitor
Product Description
Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor (IC50 = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.Product Specifications
Molecular Weight
377.31
Formula
C19H21ClN4.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine hydrochloride
CAS Number
2250025-95-5
PubChem ID
134160236
InChI Key
HEHOHTKMIOBTKC-UHFFFAOYSA-N
SMILES
C1CNCCC12C(=NC3=CC=CC=C3N2)NCC4=CC(=CC=C4)Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.73 | 100 |
Preparing Stock Solutions
for Liproxstatin-1 hydrochloride
The following data is based on the product molecular weight 377.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.25 mL | 26.50 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.30 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Friedmann Angeli Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat.Cell.Biol. 2014 PMID: 25402683
Product Specific Notices for Liproxstatin-1 hydrochloride
For research use only
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