Licarbazepine
Tocris Bioscience, part of Bio-Techne | Catalog # 3865
Active metabolite of oxcarbazepine (Cat. No. 3864)
Key Product Details
Description
Active metabolite of oxcarbazepine (Cat. No. 3864)
Alternative Names
GP 47779
Product Description
Licarbazepine is an active metabolite of oxcarbazepine (Cat. No. 3864). Produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Displays anticonvulsant activity; exhibits minor potentiation of GABAA receptor currents.Product Specifications
Molecular Weight
254.28
Formula
C15H14N2O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide
CAS Number
29331-92-8
PubChem ID
114709
InChI Key
BMPDWHIDQYTSHX-UHFFFAOYSA-N
SMILES
NC(N2C1=CC=CC=C1C(O)CC3=C2C=CC=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.43 | 100 |
Preparing Stock Solutions
for Licarbazepine
The following data is based on the product molecular weight 254.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.93 mL | 19.66 mL | 39.33 mL |
| 5 mM | 0.79 mL | 3.93 mL | 7.87 mL |
| 10 mM | 0.39 mL | 1.97 mL | 3.93 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Benes Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J.Med.Chem. 1999 PMID: 10411478
- Zheng Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 2009 PMID: 18717705
- Calabresi Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission. Epilepsia 1995 PMID: 7555963
Product Specific Notices for Licarbazepine
For research use only
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