Liarozole dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2705

Blocks retinoic acid metabolism
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Key Product Details

Description

Blocks retinoic acid metabolism

Alternative Names

R-75251

View all Additional Retinoic Acid Receptor Compounds »

Product Description

Liarozole dihydrochloride is a cytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas.

Product Specifications

Molecular Weight

381.69

Formula

C17H13ClN4.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole dihydrochloride

CAS Number

1883548-96-6

PubChem ID

121513844

InChI Key

NKDMRTVUEJWCCQ-UHFFFAOYSA-N

SMILES

ClC1=CC(C(N4C=CN=C4)C2=CC=C(N=CN3)C3=C2)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 34.52 100
DMSO 38.17 100

Preparing Stock Solutions for Liarozole dihydrochloride

The following data is based on the product molecular weight 381.69

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.10 mL 26.20 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Liarozole dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Liarozole dihydrochloride

For research use only

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