Liarozole dihydrochloride

Name: Liarozole dihydrochloride
Brand: Tocris Bioscience
SKU: 2705

Tocris Bioscience, part of Bio-Techne | Catalog # 2705

Citations (9)

COA / SDS

Blocks retinoic acid metabolism

Key Product Details

Description:	Blocks retinoic acid metabolism
Alternative Names:	R-75251
Chemical Name:	5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	381.69

View Full Technical Details for Liarozole dihydrochloride

Technical Data
Citations

Biological Activity for Liarozole dihydrochloride

Liarozole dihydrochloride is a cytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas.

Compound Libraries for Liarozole dihydrochloride

Liarozole dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Liarozole dihydrochloride

M. Wt	381.69
Formula	C₁₇H₁₃ClN₄.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1883548-96-6
PubChem ID	121513844
InChi Key	NKDMRTVUEJWCCQ-UHFFFAOYSA-N
Smiles	ClC1=CC(C(N4C=CN=C4)C2=CC=C(N=CN3)C3=C2)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Liarozole dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.17	100
	water	34.52	100

Preparing Stock Solutions for Liarozole dihydrochloride

The following data is based on the product molecular weight 381.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.10 mL	26.20 mL
5 mM	0.52 mL	2.62 mL	5.24 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for Liarozole dihydrochloride

References are publications that support the biological activity of the product.

Njar Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases. Bioorg.Med.Chem. 2006 PMID: 16530416
Goss Effects of liarozole fumarate (R85246) in combination with tamox. on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model. BMC Cancer 2007 PMID: 17266767
Van Wauwe Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. J.Pharmacol.Exp.Ther. 1992 PMID: 1374473