LFM-A13
Tocris Bioscience, part of Bio-Techne | Catalog # 1300
Potent, selective BTK inhibitor
Key Product Details
Description
Potent, selective BTK inhibitor
Product Description
LFM-A13 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 value of 2.5 μM and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μM.Product Specifications
Molecular Weight
360.00
Formula
C11H8Br2N2O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
CAS Number
62004-35-7
PubChem ID
54676905
InChI Key
UVSVTDVJQAJIFG-VURMDHGXSA-N
SMILES
C\C(O)=C(/C#N)C(=O)NC1=C(Br)C=CC(Br)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36 | 100 |
Preparing Stock Solutions
for LFM-A13
The following data is based on the product molecular weight 360.00
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.78 mL | 13.89 mL | 27.78 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mahajan Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide]. J.Biol.Chem. 1999 PMID: 10092645
- Vassilev Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. J.Biol.Chem. 1999 PMID: 9880544
- Crosby and Pool Interaction of Bruton's tyrosine kinase and protein kinase Cθ in platelets. J.Biol.Chem. 2002 PMID: 11788586
Product Specific Notices for LFM-A13
For research use only
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