Lei-Dab 7

Name: Lei-Dab 7
Brand: Tocris Bioscience
SKU: 5571
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5571

(1)

Citations (4)

COA / SDS

High affinity and selective KCa2.2 (SK) blocker

Discontinued Product

5571 has been discontinued. View all Ca2+-Activated Potassium Channel Blockers products.

Key Product Details

Description:	High affinity and selective K_Ca2.2 (SK) blocker
Purity:	≥95%
Molecular Weight:	3392.06

View Full Technical Details for Lei-Dab 7

Technical Data
Citations / Reviews (1)

Biological Activity for Lei-Dab 7

Lei-Dab 7 is a high affinity, selective K_Ca2.2 (SK2) channel blocker (K_d = 3.8 nM). Exhibits >200-fold selectivity for K_Ca2.2 over K_Ca2.1, K_Ca2.3, K_Ca3.1, IK, K_v and K_ir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive in vivo.

Technical Data for Lei-Dab 7

M. Wt	3392.06
Formula	C₁₄₁H₂₃₆N₄₆O₃₉S₆
Single Letter Sequence	AFCNLRXCQLSCRSLGLLGKCIGDKCECVKH (Modifications: X = Dab, Disulfide bridges: 3-21, 8-26, 12-28, His-31 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95%
CAS Number	1061556-49-7
Smiles	[H]N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](*)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Lei-Dab 7

References are publications that support the biological activity of the product.

Kramar A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor. J.Neurosci. 2004 PMID: 15175384
Kasumu Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem.Biol. 2012 PMID: 23102227
Shakkottai Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K⁺ channel, Sk_Ca2. J.Biol.Chem. 2001 PMID: 11527975

Lei-Dab 7

Tocris Bioscience, part of Bio-Techne | Catalog # 5571

Key Product Details

Biological Activity for Lei-Dab 7

Technical Data for Lei-Dab 7

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Lei-Dab 7

Product Documents for Lei-Dab 7

COA

Certificate of Analysis

SDS

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