Laulimalide

Name: Laulimalide
Brand: Tocris Bioscience
SKU: 4007

Tocris Bioscience, part of Bio-Techne | Catalog # 4007

COA / SDS

Microtubule stabilzing agent

Discontinued Product

4007 has been discontinued. View all Microtubule Binding Compounds products.

Key Product Details

Description:	Microtubule stabilzing agent
Alternative Names:	Fijianolide B
Chemical Name:	(1R,3S,7S,8S,10S,12S,15Z,18R)-12-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]-1-hydroxy-2-propen-1-yl]-7-hydroxy-3-methyl-5-methylene-9,13,22-trioxatricyclo[16.3.1.0^8,10]docosa-15,19-dien-14-one
Purity:	≥97% (HPLC)
Molecular Weight:	514.65

View Full Technical Details for Laulimalide

Technical Data
Citations

Biological Activity for Laulimalide

Laulimalide is a microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC₅₀ reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles.

Technical Data for Laulimalide

M. Wt	514.65
Formula	C₃₀H₄₂O₇
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	115268-43-4
PubChem ID	6918457
InChi Key	MSBQEQDLFWWWMV-XZZGLLCESA-N
Smiles	O=C(O[C@H]([C@@H](O)/C=C/[C@]1([H])CC(C)=CCO1)C[C@]2([H])O[C@@]2([H])[C@@H](O)C3)/C=C\C[C@]4([H])C=CC[C@](C[C@@H](C)CC3=C)([H])O4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Laulimalide

References are publications that support the biological activity of the product.

Bennett Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization. Cell Cycle. 2012 PMID: 22871740
Bennett Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping. Chem.Biol. 2010 PMID: 20659685
Pryor The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety for activity. Biochemistry. 2002 PMID: 12119025

Laulimalide

Tocris Bioscience, part of Bio-Techne | Catalog # 4007

Key Product Details

Biological Activity for Laulimalide

Technical Data for Laulimalide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Laulimalide

Product Documents for Laulimalide

COA

Certificate of Analysis

SDS

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