Lalistat 1

Tocris Bioscience, part of Bio-Techne | Catalog # 6098

Potent and selective LAL inhibitor
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Key Product Details

Description

Potent and selective LAL inhibitor

View all Lysosomal Acid Lipase Inhibitors »

Product Description

Lalistat 1 is a potent and selective lysosomal acid lipase (LAL) inhibitor (IC50 = 68 nM). Exhibits no significant activity against pancreatic lipase or lipoprotein lipase at 10 μM concentration. Blocks LAL-mediated lipid hydrolysis of acetylated LDL and reduces efflux of cholesterol from lipid-loaded cells resulting in increased cellular cholesterol ester levels.

Product Specifications

Molecular Weight

298.36

Formula

C12H18N4O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate

CAS Number

501104-16-1

PubChem ID

648404

InChI Key

GKOPFXFKPASEFI-UHFFFAOYSA-N

SMILES

O=C(OC1=NSN=C1N2CCCCC2)N3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.84 100
Ethanol 29.84 100

Preparing Stock Solutions for Lalistat 1

The following data is based on the product molecular weight 298.36

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.76 mL 33.52 mL
5 mM 0.67 mL 3.35 mL 6.70 mL
10 mM 0.34 mL 1.68 mL 3.35 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Lalistat 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Lalistat 1

For research use only

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