LaKe

Name: LaKe
Brand: Tocris Bioscience
SKU: 8888

Tocris Bioscience, part of Bio-Techne | Catalog # 8888

COA / SDS

Orally bioavailable prodrug metabolite, undergoes hydrolytic conversion to yield (S)-lactate and (R)-1,3-butanediol in cells

Key Product Details

Description:	Orally bioavailable prodrug metabolite, undergoes hydrolytic conversion to yield (S)-lactate and (R)-1,3-butanediol in cells
Chemical Name:	(3R)-3-Hydroxybutyl (2S)-2-hydroxypropanoate and (1R)-3-Hydroxy-1-methylpropyl (2S)-2-hydroxypropanoate
Purity:	≥95%
Molecular Weight:	162.19

View Full Technical Details for LaKe

Technical Data
Citations

Biological Activity for LaKe

LaKe is a metabolite that undergoes hydrolytic conversion to yield (S)-lactate (Lac) and (R)-1,3-butanediol (BHB) in cells, two metabolites naturally released during strenuous exercise and prolonged fasting. In vivo, oral ingestion of LaKe in rats, results in an increase of Lac and BHB plasma levels, triggering reduced lipolysis and elevation of the appetite-suppressing compound Lac-Phe (Cat. No. 7942).

Licensing Information

Sold under license from Mmimetika Biosciences

Technical Data for LaKe

M. Wt	162.19
Formula	C₇H1₄O₄
Storage	Store at -20°C
Purity	≥95%
InChi Key	YYIHZASOYSUEJO-NTPRZCPUSA-N
Smiles	C[C@@H](C(O[C@@H](CCO)C)=O)O.C[C@@H](C(OCC[C@@H](C)O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LaKe

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	16.22	100

Preparing Stock Solutions for LaKe

The following data is based on the product molecular weight 162.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.17 mL	30.83 mL	61.66 mL
5 mM	1.23 mL	6.17 mL	12.33 mL
10 mM	0.62 mL	3.08 mL	6.17 mL
50 mM	0.12 mL	0.62 mL	1.23 mL

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References for LaKe

References are publications that support the biological activity of the product.

Ottosen Preparation and preclinical characterization of a simple ester for dual exogenous supply of lactate and beta-hydroxybutyrate. J.Agric.Food Chem. 2024 PMID: 39214666