LaKe

Tocris Bioscience, part of Bio-Techne | Catalog # 8888

Orally bioavailable prodrug metabolite, undergoes hydrolytic conversion to yield (S)-lactate and (R)-1,3-butanediol in cells
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Key Product Details

Description

Orally bioavailable prodrug metabolite, undergoes hydrolytic conversion to yield (S)-lactate and (R)-1,3-butanediol in cells

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Product Description

LaKe is a metabolite that undergoes hydrolytic conversion to yield (S)-lactate (Lac) and (R)-1,3-butanediol (BHB) in cells, two metabolites naturally released during strenuous exercise and prolonged fasting. In vivo, oral ingestion of LaKe in rats, results in an increase of Lac and BHB plasma levels, triggering reduced lipolysis and elevation of the appetite-suppressing compound Lac-Phe (Cat. No. 7942).

Licensing Information

Sold under license from Mmimetika Biosciences

Product Specifications

Molecular Weight

162.19

Formula

C7H14O4

Storage

Store at -20°C

Purity

≥95%

Chemical Name

(3R)-3-Hydroxybutyl (2S)-2-hydroxypropanoate and (1R)-3-Hydroxy-1-methylpropyl (2S)-2-hydroxypropanoate

InChI Key

YYIHZASOYSUEJO-NTPRZCPUSA-N

SMILES

C[C@@H](C(O[C@@H](CCO)C)=O)O.C[C@@H](C(OCC[C@@H](C)O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.22 100

Preparing Stock Solutions for LaKe

The following data is based on the product molecular weight 162.19

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.17 mL 30.83 mL 61.66 mL
5 mM 1.23 mL 6.17 mL 12.33 mL
10 mM 0.62 mL 3.08 mL 6.17 mL
50 mM 0.12 mL 0.62 mL 1.23 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for LaKe

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LaKe

For research use only

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