L-Quisqualic acid
Tocris Bioscience, part of Bio-Techne | Catalog # 0188
AMPA agonist; also group I mGlu agonist
Key Product Details
Description
AMPA agonist; also group I mGlu agonist
Product Description
L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. L-Quisqualic acid sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect).Product Specifications
Molecular Weight
189.13
Formula
C5H7N3O5
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
(L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
CAS Number
52809-07-1
PubChem ID
40539
InChI Key
ASNFTDCKZKHJSW-REOHCLBHSA-N
SMILES
O=C1N(C[C@]([H])(N)C(O)=O)OC(N1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.89 | 10 | |
| 1eq. NaOH | 18.91 | 100 |
Preparing Stock Solutions
for L-Quisqualic acid
The following data is based on the product molecular weight 189.13
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.29 mL | 26.44 mL | 52.87 mL |
| 5 mM | 1.06 mL | 5.29 mL | 10.57 mL |
| 10 mM | 0.53 mL | 2.64 mL | 5.29 mL |
| 50 mM | 0.11 mL | 0.53 mL | 1.06 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Porter (S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor. Br.J.Pharmacol. 1992 PMID: 1324071
- Schulte Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994 PMID: 7953634
- Littman Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus. Neuropharmacology 1995 PMID: 8532164
Product Specific Notices for L-Quisqualic acid
For research use only
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