L-Buthionine sulfoximine
Tocris Bioscience, part of Bio-Techne | Catalog # 6954
Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis
Key Product Details
Description
Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis
Product Description
L-Buthionine sulfoximine is an irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; depletes glutathione levels by inhibiting synthesis. Induces ferroptosis in vitro.Product Specifications
Molecular Weight
222.30
Formula
C8H18N2O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
CAS Number
83730-53-4
PubChem ID
119565
InChI Key
KJQFBVYMGADDTQ-CVSPRKDYSA-N
SMILES
CCCC[S](=N)(=O)CC[C@H](N)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.23 | 100 | |
| DMSO | 22.23 | 100 |
Preparing Stock Solutions
for L-Buthionine sulfoximine
The following data is based on the product molecular weight 222.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.50 mL | 22.49 mL | 44.98 mL |
| 5 mM | 0.90 mL | 4.50 mL | 9.00 mL |
| 10 mM | 0.45 mL | 2.25 mL | 4.50 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.90 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Griffith Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J.Biol.Chem. 1982 PMID: 6128339
- Yang Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 PMID: 24439385
- Griffith & Meister Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine) J.Biol.Chem. 1979 PMID: 38242
Product Specific Notices for L-Buthionine sulfoximine
For research use only
Loading...
Loading...