L-803,087 trifluoroacetate
Tocris Bioscience, part of Bio-Techne | Catalog # 1979
Potent and selective sst4 agonist
Discontinued Product
1979 has been discontinued.
View all Somatostatin Receptor Agonists products.
Key Product Details
Description
Potent and selective sst4 agonist
Product Description
L-803,087 trifluoroacetate is a potent and selective somatostatin sst4 receptor agonist. Ki values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4, sst1, sst2, sst3 and sst5 receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo.Product Specifications
Molecular Weight
599.56
Formula
C25H29F2N5O3.CF3CO2H
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
N2-[4-(5,7-Difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-L-arginine methyl ester trifluoroacetate
CAS Number
1786412-46-1
PubChem ID
45073436
InChI Key
IIRYZHRNVKQVGQ-BDQAORGHSA-N
SMILES
FC(F)(F)C(O)=O.NC(NCCC[C@@H]([C@@](OC)=O)NC(CCCC1=C(C3=CC=CC=C3)NC2=C1C=C(F)C=C2F)=O)=N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.96 | 100 | |
| Ethanol | 59.96 | 100 |
Preparing Stock Solutions
for L-803,087 trifluoroacetate
The following data is based on the product molecular weight 599.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.67 mL | 8.34 mL | 16.68 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.67 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rohrer and Schaeffer Identification and characterization of subtype selective somatostatin receptor agonists. J.Physiol.Paris 2000 PMID: 11087999
- Moneta Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur.J.Neurosci. 2002 PMID: 12372020
- Rohrer Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 1998 PMID: 9784130
Product Specific Notices for L-803,087 trifluoroacetate
For research use only
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