L-703,664 succinate

Name: L-703,664 succinate
Brand: Tocris Bioscience
SKU: 2640

Tocris Bioscience, part of Bio-Techne | Catalog # 2640

COA / SDS

Selective 5-HT1D agonist

Discontinued Product

2640 has been discontinued. View all 5-HT1D Receptor Agonists products.

Key Product Details

Description:	Selective 5-HT_1D agonist
Chemical Name:	N,N-Dimethyl-5-[(5-methyl-1,1-dioxodo-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole-3-ethanamine succinate
Purity:	≥99% (HPLC)
Molecular Weight:	454.54

View Full Technical Details for L-703,664 succinate

Technical Data
Citations

Biological Activity for L-703,664 succinate

L-703,664 succinate is a 5-HT_1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC₅₀ values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT_1D, 5-HT_1A, 5-HT_2A and 5-HT₃ respectively) and other receptors (pIC₅₀ < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).

Licensing Information

Sold with the permission of Merck, Sharpe and Dohme Ltd.

Technical Data for L-703,664 succinate

M. Wt	454.54
Formula	C₁₆H₂₄N₄O₂S.C₄H₆O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	144776-01-2
PubChem ID	90488774
InChi Key	WLXRLNXDMGIORD-UHFFFAOYSA-N
Smiles	O=S1(N(CCN1C)CC2=CC=C(NC=C3CCN(C)C)C3=C2)=O.O=C(CCC(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for L-703,664 succinate

References are publications that support the biological activity of the product.

Castro Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT_1D receptor. J.Med.Chem. 1994 PMID: 7932524