L-701,324
Tocris Bioscience, part of Bio-Techne | Catalog # 0907
NMDA antagonist; acts at glycine site
Key Product Details
Description
NMDA antagonist; acts at glycine site
Product Description
L-701,324 is a an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.Product Specifications
Molecular Weight
363.80
Formula
C21H14ClNO3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
CAS Number
142326-59-8
PubChem ID
54682505
InChI Key
FLVRDMUHUXVRET-UHFFFAOYSA-N
SMILES
OC1=C(C(=O)NC2=CC(Cl)=CC=C12)C1=CC=CC(OC2=CC=CC=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 |
Preparing Stock Solutions
for L-701,324
The following data is based on the product molecular weight 363.80
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.74 mL | 27.49 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.50 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.75 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Obrenovitch and Zilkha Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-MthD.-aspartate receptor complex. Br.J.Pharmacol. 1996 PMID: 8851513
- Bristow Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-MthD.-aspartate receptor complex. J.Pharmacol.Exp.Ther. 1996 PMID: 8930150
- Kulagowski 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. J.Med.Chem. 1994 PMID: 8182696
- Bristow The atypical neuroleptic profile of the glycine/N-MthD.-aspartate receptor antagonist, L-701,324 in rodents. J.Pharmacol.Exp.Ther. 1996 PMID: 8627534
Product Specific Notices for L-701,324
For research use only
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