L-689,560

Name: L-689,560
Brand: Tocris Bioscience
SKU: 0742

Tocris Bioscience, part of Bio-Techne | Catalog # 0742

Citations (64)

COA / SDS

Highly potent NMDA antagonist

Key Product Details

Description:	Highly potent NMDA antagonist
Chemical Name:	trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
Purity:	≥98% (HPLC)
Molecular Weight:	380.23

View Full Technical Details for L-689,560

Technical Data
Citations

Biological Activity for L-689,560

L-689,560 is a very potent antagonist at the glycine-NMDA site.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Compound Libraries for L-689,560

L-689,560 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-689,560

M. Wt	380.23
Formula	C₁₇H₁₅Cl₂N₃O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	139051-78-8
PubChem ID	6604749
InChi Key	UCKHICKHGAOGAP-UONOGXRCSA-N
Smiles	ClC1=C2C(N[C@@H]([C@](O)=O)C[C@@H]2NC(NC3=CC=CC=C3)=O)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-689,560

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	9.51	25
	ethanol	38.02	100

Preparing Stock Solutions for L-689,560

The following data is based on the product molecular weight 380.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.15 mL	26.30 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for L-689,560

References are publications that support the biological activity of the product.

Stone Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 2000 PMID: 10740291
Leeson trans-2-Carboxy-4-substituted tetrahydroquinolines. Potent glycine-site NMDA receptor antagonists. Med.Chem.Res.
Leeson 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationship for antagonism at the glycine site of the NMDA receptor. J.Med.Chem. 1992 PMID: 1534584