KS 176
Tocris Bioscience, part of Bio-Techne | Catalog # 4169
Selective BCRP inhibitor
Key Product Details
Description
Selective BCRP inhibitor
Product Description
KS 176 is a selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.Product Specifications
Molecular Weight
405.40
Formula
C22H19N3O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]benzamide
CAS Number
1253452-78-6
PubChem ID
49779726
InChI Key
LTWQQWSXYYXVGA-UHFFFAOYSA-N
SMILES
OCCC1=CC=C(NC(C2=C(NC(C3=CC=C([N+]([O-])=O)C=C3)=O)C=CC=C2)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.54 | 100 |
Preparing Stock Solutions
for KS 176
The following data is based on the product molecular weight 405.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.33 mL | 24.67 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pick Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem 2010 PMID: 20632361
Product Specific Notices for KS 176
For research use only
Loading...
Loading...