Kobe 0065
Tocris Bioscience, part of Bio-Techne | Catalog # 5475
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling
Discontinued Product
5475 has been discontinued.
View all Raf Kinase Inhibitors products.
Key Product Details
Description
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling
Product Description
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.Product Specifications
Molecular Weight
449.79
Formula
C15H11ClF3N5O4S
Storage
Store at +4°C
Chemical Name
N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
CAS Number
436133-68-5
PubChem ID
3827663
InChI Key
KSJVAYBCXSURMQ-UHFFFAOYSA-N
SMILES
CC1=C(Cl)C=C(NC(NNC2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2[N+]([O-])=O)=S)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.25 | 5 with gentle warming | |
| Ethanol | 4.5 | 10 with gentle warming |
Preparing Stock Solutions
for Kobe 0065
The following data is based on the product molecular weight 449.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.23 mL | 111.16 mL | 222.33 mL |
| 0.5 mM | 4.45 mL | 22.23 mL | 44.47 mL |
| 1 mM | 2.22 mL | 11.12 mL | 22.23 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shima In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 23630290
Product Specific Notices for Kobe 0065
For research use only
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