KM 11060
Tocris Bioscience, part of Bio-Techne | Catalog # 3143
Corrects F508del-CFTR trafficking
Discontinued Product
3143 has been discontinued.
View all Other CFTR Compounds products.
Product Description
KM 11060 is a corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.Product Specifications
Molecular Weight
422.33
Formula
C19H17Cl2N3O2S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
CAS Number
774549-97-2
PubChem ID
1241327
InChI Key
GIEHIZKCIZLXLF-UHFFFAOYSA-N
SMILES
ClC(C=C4)=CC=C4S(N(CC3)CCN3C1=CC=NC2=C1C=CC(Cl)=C2)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.23 | 100 | |
| Ethanol | 4.22 | 10 |
Preparing Stock Solutions
for KM 11060
The following data is based on the product molecular weight 422.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.84 mL | 23.68 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Robert Structural analog of silde. identified as a novel corrector of the F508del-CFTR trafficking defect. Mol.Pharmacol. 2008 PMID: 17975008
Product Specific Notices for KM 11060
For research use only
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