KLH 45

Name: KLH 45
Brand: Tocris Bioscience
SKU: 5865

Tocris Bioscience, part of Bio-Techne | Catalog # 5865

COA / SDS

Potent DDHD2 inhibitor

Discontinued Product

5865 has been discontinued. View all Hydrolase Inhibitors products.

Key Product Details

Description:	Potent DDHD2 inhibitor
Chemical Name:	N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	458.48

View Full Technical Details for KLH 45

Technical Data
Citations

Biological Activity for KLH 45

KLH 45 is a potent DDHD2 inhibitor (IC₅₀ = 1.3 nM). Selective for DDHD2 over 40 other serine hydrolases, but does exhibit cross-reactivity with ABHD6. Active in vivo. Increases brain triacylglycerol levels in mice.

Licensing Information

Sold under license from The Scripps Research Institute

Technical Data for KLH 45

M. Wt	458.48
Formula	C₂₄H₂₅F₃N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1632236-44-2
PubChem ID	126970670
InChi Key	FYOYNRLSBYWAHL-UHFFFAOYSA-N
Smiles	O=C(N(C1CCCCC1)CCC2=CC=CC=C2)N(N=C3)N=C3C(C=C4)=CC=C4OC(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for KLH 45

References are publications that support the biological activity of the product.

Inloes The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 25267624