KL 001

Name: KL 001
Brand: Tocris Bioscience
SKU: 4685

Tocris Bioscience, part of Bio-Techne | Catalog # 4685

Citations (5)

COA / SDS

Cryptochrome protein stabilizer; lengthens circadian period

Key Product Details

Description:	Cryptochrome protein stabilizer; lengthens circadian period
Chemical Name:	N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	398.48

View Full Technical Details for KL 001

Technical Data
Citations

Biological Activity for KL 001

KL 001 is a cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.

Technical Data for KL 001

M. Wt	398.48
Formula	C₂₁H₂₂N₂O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	309928-48-1
PubChem ID	2888648
InChi Key	OQAFDLPAPSSOHY-UHFFFAOYSA-N
Smiles	OC(CN(CC4=CC=CO4)S(C)(=O)=O)CN2C1=CC=CC=C1C3=C2C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KL 001

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.85	100
	ethanol	7.97	20

Preparing Stock Solutions for KL 001

The following data is based on the product molecular weight 398.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.55 mL	25.10 mL
5 mM	0.50 mL	2.51 mL	5.02 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for KL 001

References are publications that support the biological activity of the product.

Hirota Identification of small molecule activators of cryptochrome. Science 2012 PMID: 22798407