Kifunensine

Product Description

Kifunensine is an inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Kifunensine inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with K_i values of 130 and 23 nM respectively. Kifunensine disrupts normal trafficking of the GLUT1 transporter, leading to decreased glucose uptake in human renal epithelial cells. Kifunensine impaires tumour cell aggregation in human ovarian cancer cells in vitro.

Solubility

Preparing Stock Solutions for Kifunensine

The following data is based on the product molecular weight 232.19

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	86.14 mL	430.68 mL	861.36 mL
0.25 mM	17.23 mL	86.14 mL	172.27 mL
0.5 mM	8.61 mL	43.07 mL	86.14 mL
2.5 mM	1.72 mL	8.61 mL	17.23 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hamester Prognostic relevance of the Golgi mannosidase MAN1A1 in ovarian cancer: impact of N-glycosylation on tumour cell aggregation. Br.J.Cancer 2019 PMID: 31659304
• Elbein Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem.
• Xiong Pharmacologic inhibition of N-linked glycan trimming with kifunensine disrupts GLUT1 trafficking and glucose uptake. Int.J.Mol.Sci. 2018 PMID: 29562594
• Hering A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 2005 PMID: 16292820