Ketoconazole

Name: Ketoconazole
Brand: Tocris Bioscience
SKU: 1103

Tocris Bioscience, part of Bio-Techne | Catalog # 1103

Citations (20)

COA / SDS

Cytochrome P450c17 inhibitor

Key Product Details

Description:	Cytochrome P450c17 inhibitor
Chemical Name:	cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy]phenyl]piperazine
Purity:	≥98% (HPLC)
Molecular Weight:	531.44

View Full Technical Details for Ketoconazole

Technical Data
Citations

Biological Activity for Ketoconazole

Ketoconazole is an inhibitor of cytochrome P450c17. Enhances the formation of myelin basic protein-positive oligodendrocytes from oligodendrocyte progenitor cells in vitro and promotes remyelination in vivo. Also an antifungal agent. Brain penetrant.

Technical Data for Ketoconazole

M. Wt	531.44
Formula	C₂₆H₂₈Cl₂N₄O₄
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	65277-42-1
PubChem ID	456201
InChi Key	XMAYWYJOQHXEEK-OZXSUGGESA-N
Smiles	ClC1=CC(Cl)=[C@]([C@]3(OC[C@@](COC4=CC=C(N5CCN(C(C)=O)CC5)C=C4)([H])O3)CN2C=CN=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ketoconazole

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	26.57	50
	DMSO	39.86	75

Preparing Stock Solutions for Ketoconazole

The following data is based on the product molecular weight 531.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	2.51 mL	12.54 mL	25.09 mL
3.75 mM	0.50 mL	2.51 mL	5.02 mL
7.5 mM	0.25 mL	1.25 mL	2.51 mL
37.5 mM	0.05 mL	0.25 mL	0.50 mL

Molarity Calculator

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Reconstitution Calculator

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References for Ketoconazole

References are publications that support the biological activity of the product.

Madhavan Induction of myelinating oligodendrocytes in human cortical spheroids. Nat.Methods. 2018 PMID: 30046099
Hubler Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 2018 PMID: 30046109
Dumaine Blockade of HERG and Kv1.5 by ketoconazole. J.Pharmacol.Exp.Ther. 1998 PMID: 9694927
Kuhn-Velten Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. Biochem.Pharmacol. 1992 PMID: 1472102
Ayub and Levell Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J.Steroid Biochem. 1989 PMID: 2724954