Ketamine hydrochloride

Name: Ketamine hydrochloride
Brand: Tocris Bioscience
SKU: 3131
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3131

(1)

Citations (47)

COA / SDS

Non-competitive NMDA receptor antagonist

Key Product Details

Description:	Non-competitive NMDA receptor antagonist
Chemical Name:	2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	274.19

View Full Technical Details for Ketamine hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Ketamine hydrochloride

Ketamine hydrochloride is a non-competitive NMDA receptor antagonist (EC₅₀ values are 13.6 and 17.6 μM for GluN1/GluN2A (formally NR1 and NR2A, respectively) and GluN1/GluN2B (formally NR1 and NR2B, respectively) subunit combinations respectively). Dissociative anesthetic.

S-enantiomer and Active metabolite also available.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions. .

Technical Data for Ketamine hydrochloride

M. Wt	274.19
Formula	C₁₃H₁₆ClNO.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1867-66-9
PubChem ID	15851
InChi Key	VCMGMSHEPQENPE-UHFFFAOYSA-N
Smiles	O=C1C(C2=CC=CC=C2Cl)(NC)CCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ketamine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	27.42	100

Preparing Stock Solutions for Ketamine hydrochloride

The following data is based on the product molecular weight 274.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.65 mL	18.24 mL	36.47 mL
5 mM	0.73 mL	3.65 mL	7.29 mL
10 mM	0.36 mL	1.82 mL	3.65 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Ketamine hydrochloride

References are publications that support the biological activity of the product.

Pallares Effects of KA, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats. Physiol.Behav. 1995 PMID: 7716221
Liu Modulation of NMDA receptor function by KA and magnesium: part I. Anesth.Pharmacol.
Anis The dissociative anaesthetics, KA and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 1983 PMID: 6317114