K 252a

Tocris Bioscience, part of Bio-Techne | Catalog # 1683

Protein kinase inhibitor
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Key Product Details

Description

Protein kinase inhibitor

Alternative Names

SF 2370

View all Broad Spectrum Protein Kinase Inhibitors »

Product Description

K 252a is a non-selective protein kinase inhibitor; analog of staurosporine (Cat.No. 1285). Inhibits PKC (IC50 = 32.9 nM), Ca2+/calmodulin-stimulated phosphodiesterases (IC50 = 1.3 - 2.9 μM), MLCK (Ki = 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).

Product Specifications

Molecular Weight

467.48

Formula

C27H21N3O5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolopyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester

CAS Number

99533-80-9

PubChem ID

3035817

InChI Key

KOZFSFOOLUUIGY-SOLYNIJKSA-N

SMILES

[H][C@](C[C@]8(O)[C@@](OC)=O)(O[C@]78C)N5C3=C2N7C1=CC=CC=C1C2=C(CNC6=O)C6=C3C4=CC=CC=C45

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.69 25

Preparing Stock Solutions for K 252a

The following data is based on the product molecular weight 467.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 8.56 mL 42.78 mL 85.57 mL
1.25 mM 1.71 mL 8.56 mL 17.11 mL
2.5 mM 0.86 mL 4.28 mL 8.56 mL
12.5 mM 0.17 mL 0.86 mL 1.71 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for K 252a

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for K 252a

For research use only

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