K 22
Tocris Bioscience, part of Bio-Techne | Catalog # 7338
Inhibits coronavirus RNA replication; impairs double membrane vesicle (DMV) formation
Key Product Details
Description
Inhibits coronavirus RNA replication; impairs double membrane vesicle (DMV) formation
Product Description
K 22 is a viral RNA synthesis inhibitor; targets membrane-bound coronaviral RNA replication by inhibiting double membrane vesicle (DMV) formation. Inhibits HCoV-229E infection of MRC-5 cells in a plaque forming assay (IC50 = 0.7 μM). Also inhibits HCoV-229E and MERS-CoV replication in human airway epithelia cultures.Product Specifications
Molecular Weight
505.41
Formula
C27H25BrN2O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1Z)-1-[[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-2-phenylethenyl]benzamide
CAS Number
2141978-86-9
PubChem ID
5433970
InChI Key
CMBUSPXASRNJHI-CLCOLTQESA-N
SMILES
OC1(C2=CC=C(Br)C=C2)CCN(C(/C(=C/C3=CC=CC=C3)/NC(=O)C4=CC=CC=C4)=O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.54 | 100 |
Preparing Stock Solutions
for K 22
The following data is based on the product molecular weight 505.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.89 mL | 19.79 mL |
| 5 mM | 0.40 mL | 1.98 mL | 3.96 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lundin Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus. PLoS Pathog. 2014 PMID: 24874215
Product Specific Notices for K 22
For research use only
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