JZL 195

Name: JZL 195
Brand: Tocris Bioscience
SKU: 4715

Tocris Bioscience, part of Bio-Techne | Catalog # 4715

Citations (8)

COA / SDS

Dual FAAH and MAGL inhibitor

Key Product Details

Description:	Dual FAAH and MAGL inhibitor
Chemical Name:	4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	433.46

View Full Technical Details for JZL 195

Technical Data
Citations

Biological Activity for JZL 195

JZL 195 is a dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC₅₀ values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown to impair short-term memory in mice.

Compound Libraries for JZL 195

JZL 195 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JZL 195

M. Wt	433.46
Formula	C₂₄H₂₃N₃O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1210004-12-8
PubChem ID	46232606
InChi Key	QNYRAEKLMNDRFY-UHFFFAOYSA-N
Smiles	O=C(OC4=CC=C([N+]([O-])=O)C=C4)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JZL 195

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.67	50

Preparing Stock Solutions for JZL 195

The following data is based on the product molecular weight 433.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.61 mL	23.07 mL	46.14 mL
2.5 mM	0.92 mL	4.61 mL	9.23 mL
5 mM	0.46 mL	2.31 mL	4.61 mL
25 mM	0.09 mL	0.46 mL	0.92 mL

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References for JZL 195

References are publications that support the biological activity of the product.

Long Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc.Natl.Acad.Sci.USA 2009 PMID: 19918051
Wiskerke Characterization of the effects of reuptake and hydrolysis inhibiton on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem.Neurosci. 2012 PMID: 22860210
Wise Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS Chem.Neurosci. 2012 PMID: 22860205