JW 55

Name: JW 55
Brand: Tocris Bioscience
SKU: 4514

Tocris Bioscience, part of Bio-Techne | Catalog # 4514

Citations (16)

COA / SDS

Tankyrase inhibitor

Discontinued Product

4514 has been discontinued. View all Tankyrase Inhibitors products.

Key Product Details

Description:	Tankyrase inhibitor
Chemical Name:	N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	434.48

View Full Technical Details for JW 55

Technical Data
Citations

Biological Activity for JW 55

JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.

Compound Libraries for JW 55

JW 55 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of JW55 is reviewed on the chemical probes website.

Technical Data for JW 55

M. Wt	434.48
Formula	C₂₅H₂₆N₂O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	664993-53-7
PubChem ID	2946601
InChi Key	ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
Smiles	O=C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)C1=CC=C(NC(C4=CC=CO4)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for JW 55

References are publications that support the biological activity of the product.

Waaler A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012 PMID: 22440753