JTV 519 fumarate is a ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.

Product Specifications

Molecular Weight

540.67

Formula

C₂₅H₃₂N₂O₂S.C₄H₄O₄

Storage

Store at +4°C

Purity

≥97% (HPLC)

Chemical Name

1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate

CAS Number

1883549-36-7

PubChem ID

91826075

InChI Key

ISLOBKLDZGDFTB-WLHGVMLRSA-N

SMILES

O=C(CCN3CCC(CC4=CC=CC=C4)CC3)N2CCSC1=CC=C(OC)C=C1C2.O=C(/C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.07	100

Preparing Stock Solutions for JTV 519 fumarate

The following data is based on the product molecular weight 540.67

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.25 mL	18.50 mL
5 mM	0.37 mL	1.85 mL	3.70 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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Background References

References are publications that support the biological activity of the product.

Chen Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 2008 PMID: 17994112
Ye Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 2012 PMID: 21989257
Hunt K201 (JTV519) suppresses spontaneous Ca²⁺ release and [³H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 2007 PMID: 17313373

JTV 519 fumarate

Tocris Bioscience, part of Bio-Techne | Catalog # 4564

Key Product Details

Description

Alternative Names

View all Ryanodine Receptor Inhibitors »

Product Description