JT010
Tocris Bioscience, part of Bio-Techne | Catalog # 6269
Potent and selective TRPA1 channel activator
Key Product Details
Description
Potent and selective TRPA1 channel activator
Product Description
JT010 is a potent and selective TRPA1 channel activator (EC50 = 0.65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).Product Specifications
Molecular Weight
354.85
Formula
C16H19ClN2O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide
CAS Number
917562-33-5
PubChem ID
18524489
InChI Key
KZMAWJRXKGLWGS-UHFFFAOYSA-N
SMILES
O=C(N(CCCOC)C1=NC(C2=CC=C(OC)C=C2)=CS1)CCl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.48 | 100 | |
| Ethanol | 17.74 | 50 |
Preparing Stock Solutions
for JT010
The following data is based on the product molecular weight 354.85
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.09 mL | 28.18 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Takaya A potent and site-selective agonist of TRPA1. J.Am.Chem.Soc. 2015 PMID: 26630251
Product Specific Notices for JT010
For research use only
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