JP-2-196 alkyne
Tocris Bioscience, part of Bio-Techne | Catalog # 8047
RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046).
Key Product Details
Description
RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046).
Product Description
JP-2-196 alkyne is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM1. By facilitating E3 ligase recruitment, JP-2-196 alkyne induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders. JP-2-196 alkyne is an alkyne functionalized version of JP-2-196 (Cat. No. 8046).Product Specifications
Molecular Weight
312.37
Formula
C18H20N2O3
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
1-(4-Methoxyphenyl)-4-[4-(2-propyn-1-yl)-1-piperazinyl]-2-butene-1,4-dione
CAS Number
2901113-25-3
PubChem ID
167740300
InChI Key
COPXSSDNGLPYDY-CMDGGOBGSA-N
SMILES
O=C(C1=CC=C(C=C1)OC)/C=C/C(N2CCN(CC2)CC#C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.24 | 100 |
Preparing Stock Solutions
for JP-2-196 alkyne
The following data is based on the product molecular weight 312.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.20 mL | 16.01 mL | 32.01 mL |
| 5 mM | 0.64 mL | 3.20 mL | 6.40 mL |
| 10 mM | 0.32 mL | 1.60 mL | 3.20 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Toriki Rational chemical design of molecular glue Degraders. ACS Cent.Sci. 2023 PMID: 37252349
Product Specific Notices for JP-2-196 alkyne
For research use only
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