JNJ 7777120

Name: JNJ 7777120
Brand: Tocris Bioscience
SKU: 4021

Tocris Bioscience, part of Bio-Techne | Catalog # 4021

Citations (29)

COA / SDS

Selective H4 antagonist

Key Product Details

Description:	Selective H₄ antagonist
Chemical Name:	1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine
Purity:	≥98% (HPLC)
Molecular Weight:	277.75

View Full Technical Details for JNJ 7777120

Technical Data
Citations

Biological Activity for JNJ 7777120

JNJ 7777120 is a histamine H₄ receptor antagonist; displays high affinity (K_i = 4.5 nM) and is >1000-fold selective for H₄ over other histamine receptors.

Licensing Information

Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

Compound Libraries for JNJ 7777120

JNJ 7777120 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 7777120

M. Wt	277.75
Formula	C₁₄H₁₆ClN₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	459168-41-3
PubChem ID	4908365
InChi Key	HUQJRYMLJBBEDO-UHFFFAOYSA-N
Smiles	ClC1=CC=C(NC(C(N3CCN(C)CC3)=O)=C2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 7777120

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	27.77	100
	DMSO	13.89	50

Preparing Stock Solutions for JNJ 7777120

The following data is based on the product molecular weight 277.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.60 mL	18.00 mL	36.00 mL
5 mM	0.72 mL	3.60 mL	7.20 mL
10 mM	0.36 mL	1.80 mL	3.60 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for JNJ 7777120

References are publications that support the biological activity of the product.

Thurmond A potent and selective histamine H₄ receptor antagonist with anti-inflammatory properties. J.Pharmacol.Exp.Ther. 2004 PMID: 14722321
Strakhova In vitro and in vivo characterization of A-940894: a potent histamine H₄ receptor antagonist with anti-inflammatory properties. Br.J.Pharmacol. 2009 PMID: 19413570
Jablanowski The first potent and selective non-imidazole human histamine H₄ receptor antagonists. J.Med.Chem. 2003 PMID: 12954048