JNJ 63533054
Tocris Bioscience, part of Bio-Techne | Catalog # 5666
Potent and selective GPR139 agonist
Key Product Details
Description
Potent and selective GPR139 agonist
Product Description
JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.Product Specifications
Molecular Weight
316.78
Formula
C17H17ClN2O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
CAS Number
1802326-66-4
PubChem ID
2548547
InChI Key
MWDVCHRYCKXEBY-LBPRGKRZSA-N
SMILES
O=C(CNC(C1=CC=CC(Cl)=C1)=O)N[C@@H](C)C2=CC=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.68 | 100 | |
| Ethanol | 6.34 | 20 |
Preparing Stock Solutions
for JNJ 63533054
The following data is based on the product molecular weight 316.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.16 mL | 15.78 mL | 31.57 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.31 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.16 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dvorak Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor. ACS Med.Chem.Lett. 2015 PMID: 26396690
Product Specific Notices for JNJ 63533054
For research use only
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